CRB2 anticorps

N° du produit ABIN1077416

Détail du produit anti-CRB2 anticorps

Antigène: CRB2 (Crumbs Homolog 2 (CRB2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRB2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: At least three isoforms of CRB2 are known to exist, this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.

Purification: Affinity chromatography purified via peptide column

Immunogène: Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2.

Isotype: IgG

Information d'application

Indications d'application: CRB2 antibody can be used for detection of CRB2 by Western blot at 1 - 2 μg/mL.

Commentaires:

(IN) Crumbs homolog 2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C

Stockage commentaire: CRB2 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Date de péremption: 12 months

Détails sur CRB2

Antigène: CRB2 (Crumbs Homolog 2 (CRB2))

Autre désignation: CRB2 (CRB2 Produits)

Synonymes: anticorps 5930402A21, anticorps BC043114, anticorps RGD1309368, anticorps crb2, anticorps crumbs family member 2, anticorps crumbs 2, cell polarity complex component, anticorps crumbs family member 2a, anticorps Crb2, anticorps CRB2, anticorps crb2a

Sujet: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.
Synonyms: Crumbs homolog 2, crumbs 2, crumbs-like protein 2

Poids moléculaire: 141 kDa (calculated)

ID gène: 286204

NCBI Accession: NP_775960

Pathways: Signalisation Notch