ATP7B anticorps (AA 3-21)

N° du produit ABIN1098199

Détail du produit anti-ATP7B anticorps

Antigène: ATP7B (ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))

Épitope: AA 3-21

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATP7B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC)

Fonction: Anti-Copper-Transporting ATPase2 Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and rat Copper-Transporting ATPase2.

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G affinity chromatography.

Immunogène: Synthetic peptide correspond- ing to aa 3-21 (cytoplasmic N-terminus) of human Copper-Transporting ATPase2. (accession no. NP_000044.2).

Clone: S62-29

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 1-2 μg/mL. A band of ~160 kDa is detected.
Immunohistochemistry: use at 1-5 μg/mL.
These are recommended concentrations.
Enduser should determine optimal concentrations for their applications.
Positive control: rat brain membranes.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.

Détails sur ATP7B

Antigène: ATP7B (ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))

Autre désignation: Copper-Transporting ATPase2 (ATP7B Produits)

Synonymes: anticorps PWD, anticorps WC1, anticorps WD, anticorps WND, anticorps Atp7a, anticorps tx, anticorps Hts, anticorps PINA, anticorps Wd, anticorps ATP7B, anticorps ATPase copper transporting beta, anticorps ATPase, Cu++ transporting, beta polypeptide, anticorps ATPase, Cu++ transporting, beta polypeptide (Wilson disease), anticorps copper-transporting ATPase 2, anticorps ATP7B, anticorps Atp7b, anticorps atp7b, anticorps LOC592143

Sujet: P-type Cu(+) transporter,The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from cells. ATP7b (also known as Copper-Transporting ATPase2) transports copper in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene: A is found in the liver, kidney and brain, the shorter form B is found in brain, and the third isoform, known as WND/140KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver.

UniProt: B7ZLR4

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process