CBLL1 anticorps

N° du produit ABIN1105708

Détail du produit anti-CBLL1 anticorps

Antigène: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLL1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody reacts with human Hakai, a c-Cbl-like protein.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur CBLL1

Antigène: CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))

Autre désignation: CBLL1 / RNF188 (CBLL1 Produits)

Synonymes: anticorps HAKAI, anticorps RNF188, anticorps zgc:55308, anticorps CBLL1, anticorps AI467391, anticorps Hakai, anticorps c-Cbl-like, anticorps cbll1, anticorps hakai, anticorps rnf188, anticorps Cbl proto-oncogene like 1, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase S homeolog, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase, anticorps Casitas B-lineage lymphoma-like 1, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase L homeolog, anticorps CBLL1, anticorps cbll1.S, anticorps Cbll1, anticorps cbll1, anticorps cbll1.L

Sujet: Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.Synonyms: Casitas B-lineage lymphoma-transforming sequence-like protein 1, E3 ubiquitin-protein ligase Hakai, HAKAI, RING finger protein 188, c-Cbl-like protein 1

ID gène: 79872

NCBI Accession: NP_079090

UniProt: Q75N03