P-Selectin anticorps

N° du produit ABIN1106510

Détail du produit anti-P-Selectin anticorps

Antigène: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp P-Selectin est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: This antibody recognises CD62P, a 140 kDa single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, Weibel-Palade bodies in endothelial cells and megakaryocytes.

Purification: Ion Exchange Chromatography

Immunogène: Recombinant Human CD62P

Clone: B-F46

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate buffered saline containing 1 % BSA as stabilizer and 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur P-Selectin

Antigène: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Autre désignation: CD62P / P-Selectin (SELP Produits)

Synonymes: anticorps PSELECT, anticorps CD62, anticorps CD62P, anticorps GMP140, anticorps GRMP, anticorps LECAM3, anticorps PADGEM, anticorps PSEL, anticorps GMP-140, anticorps Grmp, anticorps selectin P, anticorps selectin, platelet, anticorps Selp, anticorps SELP

Sujet: CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.Synonyms: CD62 antigen-like family member P, GMP-140, GMRP, GRMP, Granule membrane protein 140, LECAM3, Leukocyte-endothelial cell adhesion molecule 3, PADGEM, SELP

ID gène: 6403

NCBI Accession: NP_002996

UniProt: P16109