CYP2E1 anticorps (C-Term)

N° du produit ABIN1106885

Détail du produit anti-CYP2E1 anticorps

Antigène: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP2E1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody detects CYP2E1 (C-term).

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide mapping at the C-terminal of human P450ⅡE1 .Remarks: Sequence is different from the related mouse sequence by single amino acid.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur CYP2E1

Antigène: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Autre désignation: CYP2E1 (CYP2E1 Produits)

Synonymes: anticorps CYP2E1, anticorps CYP2E, anticorps CYPIIE1, anticorps CPE1, anticorps P450-J, anticorps P450C2E, anticorps Cyp2e, anticorps cytochrome P450, family 2, subfamily E, polypeptide 1, anticorps cytochrome P450 2E1, anticorps cytochrome P450 2E1-like, anticorps cytochrome P450 family 2 subfamily E member 1, anticorps cytochrome P450, family 2, subfamily e, polypeptide 1, anticorps CYP2E1, anticorps PTRG_07411, anticorps LOC100342572, anticorps LOC100727914, anticorps LOC101843716, anticorps Cyp2e1

Sujet: P450IIE1, also known as CYP2E1, is a member of the P450IIE subfamily which is ethanol-inducible. It has at least 1 gene which is mapped to 10q24.3-qter, and a second is likely in rat and in man1. Both the rat and human proteins encoded by this gene contain 493 amino acids and calculated molecular masses of 56,634 and 56,916 daltons, respectively2. In addition, genetic polymorphisms in the 5-prime flanking region of the human P450IIE1 gene affected its binding of transacting factor and changed its transcriptional regulation, which may lead to interindividual differences of microsomal drug oxidation activity3. P450IIE1 is an important enzyme for the catalysis of the conversion of ethanol to acetaldehyde and to acetate in humans,and it is also involved in the metabolism of nitrosamines. Due to the possible correlation of P450IIE1 genes with malignancy, clinical studies of RFLP patterns of these genes in cancer may be useful.Synonyms: CYP2E, CYPIIE1, Cytochrome P450 2E1, Cytochrome P450-J

ID gène: 1571

NCBI Accession: NP_000764

UniProt: P05181