FHL2 anticorps
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- Antigène Voir toutes FHL2 Anticorps
- FHL2 (Four and A Half LIM Domains 2 (FHL2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FHL2 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- The monoclonal antibody F4B2-B11 reacts specifically with the LIM-only protein FHL2. It recognizes the N-terminal Zn-Finger motif, it does not cross react in Western Blot with the FHL1 and FHL3 proteins.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Protein G
- Clone
- F4B2-B11
- Isotype
- IgG1
- Top Product
- Discover our top product FHL2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2 - 8 °C.
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- Antigène
- FHL2 (Four and A Half LIM Domains 2 (FHL2))
- Autre désignation
- FHL2 / SLIM3 (FHL2 Produits)
- Synonymes
- anticorps AAG11, anticorps DRAL, anticorps FHL-2, anticorps SLIM-3, anticorps SLIM3, anticorps C76204, anticorps FHL2, anticorps zgc:92428, anticorps zgc:103466, anticorps four and a half LIM domains 2, anticorps four and a half LIM domains 2a, anticorps four and a half LIM domains 2b, anticorps FHL2, anticorps Fhl2, anticorps fhl2, anticorps fhl2a, anticorps fhl2b
- Sujet
- Five proteins share the same structural organization and a high degree of sequence homology in this group: four and a half LIM domain protein (FHL) 1, FHL2, FHL3, FHL4, and activator of cAMP-responsive element (CRE) modulator (CREM) in testis (ACT). LIM domains are constituted by a conserved cysteine- and histidine-rich structure shaped in two repeated zinc fingers first identified in the proteins encoded by the Lin-11, Isl-1, and Mec-3 genes. The LIM domain has been shown to function as a protein-protein interaction domain, and has often been described in association with other functional protein motifs, such as homeobox and kinase domains. FHL2 seems to be a promiscuous coactivator because it modulates the activity of the androgen receptor, CRE-binding protein (CREB), and WT1, although some degree of specificity is present because it is unable to stimulate CREM- and Sp1-dependent transcription. FHL2 expression was originally described to be restricted to the heart but it is inducible in other cell types. FHL2 shows specific interaction with beta-catenin, which requires the intact structure of all four LIM domains of FHL2 and the N-terminus plus the first armadillo repeat region of beta-catenin. FHL2 is a muscle-specific repressor of LEF/TCF target genes and promotes myogenic differentiation by interacting with beta-catenin.Synonyms: DRAL, FHL-2, Four and a half LIM domains protein 2, LIM domain protein DRAL, SLIM 3, Skeletal muscle LIM-protein 3
- ID gène
- 2274
- NCBI Accession
- NP_001034581
- UniProt
- Q14192
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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