p53 anticorps

N° du produit ABIN1108553

Détail du produit anti-p53 anticorps

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp p53 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody reacts to p53 (TP53).

Purification: Affinity Chromatography

Immunogène: Recombinant Human wild-type p53 protein.

Clone: IMD-53

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1.2 % Sodium Acetate or neutral PBS

Concentration: 0.1 mg/mL

Buffer: 1.2 % Sodium Acetate with 2 mg BSA and 0.01 mg Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur p53

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: p53 (TP53) (TP53 Produits)

Synonymes: anticorps BCC7, anticorps LFS1, anticorps P53, anticorps TRP53, anticorps p53, anticorps Trp53, anticorps brp53, anticorps drp53, anticorps etID22686.5, anticorps fb40d06, anticorps wu:fb40d06, anticorps zgc:111919, anticorps Tp53, anticorps bbl, anticorps bfy, anticorps bhy, anticorps p44, anticorps tp53, anticorps Xp53, anticorps TP53, anticorps tumor protein p53, anticorps cellular tumor antigen p53, anticorps transformation related protein 53, anticorps tumor protein p53 L homeolog, anticorps TP53, anticorps CpipJ_CPIJ002758, anticorps Tp53, anticorps tp53, anticorps Trp53, anticorps tp53.L

Sujet: The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53

ID gène: 7157

NCBI Accession: NP_000537

UniProt: P04637

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg