TBP anticorps (Internal Region)

N° du produit ABIN1109204

Détail du produit anti-TBP anticorps

Antigène: TBP (TATA Box Binding Protein (TBP))

Épitope: AA 39-50, Internal Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp TBP est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-TPQPIQNTNS LS

Specificité: This antibody is expected to recognize both reported Isoforms (NP_003185.1, NP_001165556.1).

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog), Porcine, Bovine.
Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_003185.1, NP_001165556.1. Genename: TBP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur TBP

Antigène: TBP (TATA Box Binding Protein (TBP))

Autre désignation: TBP (TATA-Box-Binding Protein) (TBP Produits)

Synonymes: anticorps GTF2D, anticorps GTF2D1, anticorps HDL4, anticorps SCA17, anticorps TFIID, anticorps Gtf2d, anticorps fd20h06, anticorps si:zc101n13.2, anticorps wu:fd20h06, anticorps zgc:66213, anticorps TBP1, anticorps TBP, anticorps tbp, anticorps CG9874, anticorps Dmel\\CG9874, anticorps RBP, anticorps TBP38, anticorps TFIIDtau, anticorps TfIID, anticorps dTBP, anticorps dTFIID, anticorps dTbp, anticorps dtbp, anticorps gtf2d, anticorps gtf2d1, anticorps sca17, anticorps tfiid, anticorps tfiidtau, anticorps xtbp, anticorps tbp-a, anticorps tbp-b, anticorps TATA-box binding protein, anticorps TATA box binding protein, anticorps TATA binding protein, anticorps TATA-box binding protein L homeolog, anticorps TATA-box-binding protein, anticorps TATA-box binding protein S homeolog, anticorps TBP, anticorps Tbp, anticorps tbp, anticorps tbp.L, anticorps tbp.S

Sujet: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein TBP and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. TBP is also known to interact with with HIV-1 Tat protein.Synonyms: GTF2D1, TATA-binding factor, TATA-box factor, TF2D, TFIID, Transcription initiation factor TFIID TBP subunit

Poids moléculaire: 37.7 kDa (NP_003185.1).

ID gène: 6908

NCBI Accession: NP_003185

Pathways: Signalisation WNT