CD44 anticorps (APC)

N° du produit ABIN1112149

Détail du produit anti-CD44 anticorps (APC)

Antigène: CD44

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp CD44 est conjugé à/à la APC

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Immunogène: Peripheral Blood Mononuclear cells Positive control: Peripheral Blood from a healthy donor.

Clone: HI44a

Isotype: IgG1

Information d'application

Indications d'application: It is recommended for use in flow cytometry. This reagent is effective for direct immunofluorescence staining of human tissue for flow cytometric analysis using 20 µl/10^6 cells.

Commentaires:

Allophycocyanin (Febico, Far East Bio-Tech Co.).

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Détails sur CD44

Antigène: CD44

Autre désignation: CD44 (CD44 Produits)

Synonymes: anticorps CDW44, anticorps CSPG8, anticorps ECMR-III, anticorps HCELL, anticorps HUTCH-I, anticorps IN, anticorps LHR, anticorps MC56, anticorps MDU2, anticorps MDU3, anticorps MIC4, anticorps Pgp1, anticorps AU023126, anticorps AW121933, anticorps AW146109, anticorps HERMES, anticorps Ly-24, anticorps Pgp-1, anticorps CD44A, anticorps METAA, anticorps RHAMM, anticorps XCD44, anticorps cd44, anticorps cdw44, anticorps cspg8, anticorps ecmr-iii, anticorps hcell, anticorps lhr, anticorps mc56, anticorps mdu2, anticorps mdu3, anticorps mic4, anticorps mutch-i, anticorps pgp1, anticorps CD44 molecule (Indian blood group), anticorps syndecan 4, anticorps CD44 antigen, anticorps CD44 molecule (Indian blood group) S homeolog, anticorps CD44, anticorps SDC4, anticorps Cd44, anticorps cd44.S

Sujet: The mature CD44 antigen is a transmembranous molecule which has undergone both extensive O-linked and N-linked glycosylation. The main cellular reactivity is on leucocytes and red blood cells with only weak reactivity on platelets. CD44 antigen is widely expressed on most cell types including leukocytes, erythrocytes, endothelial cells and epithelial cells, but not on platelets. CD44 is involved in leukocyte attaching and rolling on endothelial cells, homing to peripheral lymphoid organs and sites of inflammation, and leukocyte aggregation. CD44 HI44a recognizes a cell-surface glycoprotein that exists in a variety of isoforms. It is synthesized as a molecule of Mr 37 kDa s (kDa). Upon glycosylation, it is converted to an 80- to 95-kDa form. Alternatively, a 180- to 200-kDa form results from the addition of chondroitin sulfate. The CD44 antigen is present on approximately 90% of lymphocytes, monocytes, and granulocytes and in lower amounts on thymocytes, fibroblasts, and erythrocytes. The antigen mediates a variety of functions, including leucocyte-endothelial cell binding and lymphocyte homing to cer-tain peripheral lymphoid microenvironments.

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling