Insulin anticorps (INS)

Details for Product anti-INS Antibody No. ABIN111464
Antigène
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Reactivité
Humain
720
277
250
221
199
108
10
8
6
6
6
4
3
2
2
2
2
2
2
1
1
1
1
Hôte
Souris
540
221
50
4
2
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp Insulin est non-conjugé
41
29
27
15
13
13
8
8
8
8
8
8
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
335
229
193
167
167
127
107
66
56
33
32
30
23
22
21
7
5
4
4
4
3
2
2
2
1
1
1
1
1
Options
Immunogène Human C-peptide conjugated to BSA
Clone C-PEP-01
Isotype IgG1
Specificité This antibody recognises C-peptide (also known as connecting peptide) a peptide released when proinsulin is cleaved to produce insulin. It can also be used to detect proinsulin.
Réactivité croisée (Details) Also reacts to: Proinsulin
Purification Affinity chromatography on Protein A
Plasmids, Primers & others Plasmids, Primers & others Insulin products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Insulin (INS Antibody Extrait)
Sujet Synonyms: INS
ID gène 3630
NCBI Accession NP_000198
UniProt P01308
Pathways Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Indications d'application Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 0.09 % sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Produit citée dans: Meier, Köhler, Alkhatib, Sergi, Junker, Klein, Schmidt, Fritsch: "Beta-cell development and turnover during prenatal life in humans." dans: European journal of endocrinology, Vol. 162, Issue 3, pp. 559-68, 2010 (PubMed).

Background publications Hilgert, Stolba, Kristofová, Stefanová, Bendlová, Lebl, Horejsí: "A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA." dans: Hybridoma, Vol. 10, Issue 3, pp. 379-86, 1991 (PubMed).

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