FLT1 anticorps

N° du produit ABIN115150

Détail du produit anti-FLT1 anticorps

Antigène: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FLT1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Specificité: The monoclonal antibody will detect native and denaturated VEGFR-1/Flt-1 in ELISA experiments and on the surface of different Human cell types. The antibody will also detect Mouse Flt-1.

Réactivité croisée (Details): Species reactivity (tested):Human and Mouse.

Purification: Protein G Chromatography

Immunogène: Recombinant Human soluble Flt-1 protein (D5).

Clone: FLTEWC

Isotype: IgG1

Information d'application

Indications d'application: ELISA (1.5-8 μg/mL IgG1). Western blotting (1-10 μg/mL IgG1). Immunoprecipitation: (1-5 μg/mL IgG1 lysate or reaction volume).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with distilled sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 6.0 without preservatives or stabilizers

Agent conservateur: Without preservative

Stock: 4 °C/-20 °C

Stockage commentaire: The lyophilized antibody, thought stable at room temperature, is best stored desiccated below 0 °C. Reconstituted anti-VEGFR-1/Flt-1 is stable at 2-8 °C for one month or in working aliquots at -20 °C for longer.

Détails sur FLT1

Antigène: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Autre désignation: VEGFR-1 / Flt-1 (FLT1 Produits)

Synonymes: anticorps FLT, anticorps FLT-1, anticorps VEGFR-1, anticorps VEGFR1, anticorps FLT1, anticorps flt1b, anticorps sFlt1, anticorps AI323757, anticorps Flt-1, anticorps fms related tyrosine kinase 1, anticorps FMS-related tyrosine kinase 1, anticorps vascular endothelial growth factor receptor 1, anticorps fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), anticorps FMS-like tyrosine kinase 1, anticorps vascular endothelial growth factor receptor-1, anticorps FLT1, anticorps Flt1, anticorps CpipJ_CPIJ012087, anticorps flt1, anticorps FLT-1

Sujet: VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity. Because sFLT1 has a higher affinity for VEGF than does FLK1, it may function as an inhibitor of VEGF response.Synonyms: FLT, FLT1, FRT, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGF Receptor 1, VEGFR1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor

ID gène: 2321

NCBI Accession: NP_001153392

UniProt: P17948

Pathways: Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals