Cullin 7 anticorps (C-Term)

N° du produit ABIN117952

Détail du produit anti-Cullin 7 anticorps

Antigène: Cullin 7 (CUL7)

Épitope: AA 1679-1698, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 7 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human and mouse Cullin 7. Cross reactivity with other human cullins may occur.

Purification: Delipidation and defibrination.

Immunogène: Synthetic peptide corresponding to amino acids 1679-1698 of Human Cul7 (C-terminus) coupled coupled to KLH.

Information d'application

Indications d'application: Western blot (1/500-1/1,000): This antibody reacts with human Cul7, An 191.2 kDa bandcorresponding to human Cul7 is detected, Most cell lines expressing Cul7 can be used as apositive control. Immunoprecipitation: The antibody immunoprecipitates in vitro translated protein andalso protein from cell lysates (using HeLa or NIH-3T3 and others. This antibody alsoco-immunoprecipitates associated proteins in overexpressed CUL7 systems). ELISA: 1/2,000-1/10,000 Dilution.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 85.0 mg/mL (by Refractometry)

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur Cullin 7

Antigène: Cullin 7 (CUL7)

Autre désignation: Cullin-7 (CUL7 Produits)

Synonymes: anticorps cullin-7, anticorps CUL7, anticorps Cullin-7, anticorps KIAA0076, anticorps dJ20C7.5, anticorps 2510004L20Rik, anticorps AA409809, anticorps C230011P08Rik, anticorps p185, anticorps p193, anticorps cullin 7, anticorps CUL7, anticorps Cul7

Sujet: Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved proteosomal degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Cullin 7 interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.Synonyms: CUL-7, CUL7, KIAA0076

ID gène: 9820

NCBI Accession: NP_001161842

UniProt: Q14999

Pathways: ER-Nucleus Signaling