MCL-1 anticorps

N° du produit ABIN126984

Cité dans 1 publication. Cet anticorps anti-MCL-1 Polyclonal Lapin (ABIN126984) détecte spécifiquement MCL-1 dans WB, IHC (p) et IP. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Porc, Singe, Lapin et Cat.

Aperçu rapide pour MCL-1 anticorps (ABIN126984)

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivité: Humain, Souris, Rat, Chien, Porc, Singe, Lapin, Cat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCL-1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Détail du produit anti-MCL-1 anticorps

Specificité: This antibody detects Mcl-1.

Purification: Affinity Chromatography.

Immunogène: Synthetic peptide corresponding to residues surrounding amino acid 131 of human Mcl-1

Information d'application

Indications d'application: Western Blot (0.5-4 μg/mL). Immunoprecipitation (10-20 μg/mL). Immunohistochemistry (10-20 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: PBS, pH 7.2 containing 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C to -70 °C.

Références pour anticorps anti-MCL-1 (ABIN126984)

Wakatsuki, Tokunaga, Shibata, Araki: "GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration." dans: The Journal of cell biology, Vol. 216, Issue 2, pp. 477-493, (2017) (PubMed).

Détails sur MCL-1

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Autre désignation: MCL1

Sujet: Mcl-1 (Myeloid cell leukemia-1) is a 37 kDa Bcl-2-related protein with an apparent molecular weight of 43 kDa on SDS-PAGE. Mcl-1 was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-β1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004

ID gène: 4170

NCBI Accession: NP_001184249

UniProt: Q07820

Pathways: Signalisation MAPK