RPA1 anticorps (AA 201-300) (Alexa Fluor 350)

N° du produit ABIN1390059

Détail du produit anti-RPA1 anticorps (Alexa Fluor 350)

Antigène: RPA1 (Replication Protein A1, 70kDa (RPA1))

Épitope: AA 201-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPA1 est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RPA70

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur RPA1

Antigène: RPA1 (Replication Protein A1, 70kDa (RPA1))

Autre désignation: RPA70 (RPA1 Produits)

Synonymes: anticorps HSSB, anticorps MST075, anticorps REPA1, anticorps RF-A, anticorps RP-A, anticorps RPA70, anticorps Cb1-727, anticorps wu:fi14b08, anticorps zgc:55337, anticorps zgc:77092, anticorps RPA1, anticorps hssb, anticorps mst075, anticorps repa1, anticorps rf-a, anticorps rp-a, anticorps rpa, anticorps rpa70, anticorps LOC100230990, anticorps 5031405K23Rik, anticorps 70kDa, anticorps AA589576, anticorps AW557552, anticorps Rpa, anticorps CG9633, anticorps D-RPA70, anticorps D-SSB, anticorps DRP-A, anticorps DmRPA, anticorps Dmel\\CG9633, anticorps RPA, anticorps RPA 70, anticorps RPA 70 kDa, anticorps RpA70, anticorps Rpa-70, anticorps Ssb-70, anticorps dRP-A, anticorps dmrpa1, anticorps i164, anticorps replication protein A1, anticorps replication protein A1, 70kDa, anticorps replication protein A1 L homeolog, anticorps Replication Protein A 70, anticorps RPA1, anticorps Rpa1, anticorps rpa1, anticorps rpa1.L, anticorps RpA-70

Sujet:

Synonyms: Dmrpa1, Drosophila Replication Protein A, DRPA, HSSB, Human single stranded DNA binding protein, MST075, MSTP075, p70 antibody REPA1, Replication factor A, Replication factor A protein 1, Replication protein A 70 kDa DNA-binding subunit, Replication protein A 70 kDa DNA binding subunit, Replication protein A1 70 kDa, Replication protein A1, RF A, RF-A protein 1, RFA, RFA1_HUMAN, RP A, RP-A p70, RPA 70, RPA, RPA1, Single stranded binding protein 70, Single-stranded DNA-binding protein.

Background: The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a heterotrimeric SSB. RPA plays an important role in DNA replication, recombination and repair. The binding of human RPA (hRPA) to DNA involves molecular polarity in which initial hRPA binding occurs on the 5' side of an ssDNA substrate and then extends in the 3' direction to create a stably bound hRPA. RPA is a major damage-recognition protein involved in the early stages of nucleotide excision repair. It can also play a role in telomere maintenance. The RPA 70 kDa subunit binds to ssDNA and mediates interactions with many cellular and viral proteins. The DNA binding domain lies in the middle of RPA 70 kDa subunit and comprises two structurally homologous subdomains oriented in tandem. RPA contains a conserved four cysteine-type zinc-finger motif, which mediates the transition of RPA-ssDNA interaction to a stable RPA-ssDNA complex in a redox-dependent manner.

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA