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FICD anticorps (AA 161-250) (AbBy Fluor® 488)

FICD Reactivité: Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 488
N° du produit ABIN1392808
  • Antigène Voir toutes FICD Anticorps
    FICD (FIC Domain Containing (FICD))
    Épitope
    • 14
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 161-250
    Reactivité
    • 21
    • 20
    • 8
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 28
    • 5
    • 1
    Lapin
    Clonalité
    • 31
    • 3
    Polyclonal
    Conjugué
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FICD est conjugé à/à la AbBy Fluor® 488
    Application
    • 29
    • 13
    • 12
    • 12
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HYPE
    Isotype
    IgG
    Top Product
    Discover our top product FICD Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    FICD (FIC Domain Containing (FICD))
    Autre désignation
    HYPE/HIP13 (FICD Produits)
    Synonymes
    anticorps HIP13, anticorps HYPE, anticorps UNQ3041, anticorps D5Ertd40e, anticorps Hype, anticorps FIC domain containing, anticorps FICD, anticorps Ficd
    Sujet

    Synonyms: Adenosine monophosphate-protein transferase FICD, AMPylator FICD, FIC domain containing, FIC domain containing protein, FIC domain-containing protein, Fic S phase protein cell division homolog, ficd, FICD_HUMAN, HIP-13, HIP13, Huntingtin interacting protein 13, Huntingtin interacting protein E, Huntingtin interactor protein E, Huntingtin yeast partner E, Huntingtin-interacting protein 13, Huntingtin-interacting protein E.

    Background: Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5 % of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.

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