Alpha, beta Synuclein (AA 32-44) anticorps (Biotin)

N° du produit ABIN1393321

Détail du produit

Antigène: Alpha, beta Synuclein

Épitope: AA 32-44

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat, Poisson zèbre (Danio rerio)

Homologie: Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human alpha + beta Synuclein

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Alpha, beta Synuclein

Autre désignation: alpha + beta Synuclein

Sujet:

Synonyms: Alpha synuclein, Beta synuclein, NACP, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, PARK1, PARK4, Parkinson disease familial 1, PD1, SNCA, SYUA_HUMAN, SNCB, SNCB protein, Synuclein alpha, Synuclein beta, SYUB_HUMAN.

Background: Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson?s disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson?s disease, Alzheimer?s disease and several other neurodegenerative illnesses.