Acetyl-CoA Carboxylase alpha anticorps (Alexa Fluor 555)

N° du produit ABIN1394057

Détail du produit anti-Acetyl-CoA Carboxylase alpha anticorps (Alexa Fluor 555)

Antigène: Acetyl-CoA Carboxylase alpha (ACACA)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Acetyl-CoA Carboxylase alpha est conjugé à/à la Alexa Fluor 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ACACA

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Acetyl-CoA Carboxylase alpha

Antigène: Acetyl-CoA Carboxylase alpha (ACACA)

Autre désignation: Acaca (ACACA Produits)

Synonymes: anticorps ACAC, anticorps ACACAD, anticorps ACC, anticorps ACC1, anticorps ACCA, anticorps A530025K05Rik, anticorps Acac, anticorps Acc1, anticorps Gm738, anticorps AT-ACC1, anticorps EMB22, anticorps EMBRYO DEFECTIVE 22, anticorps GK, anticorps GURKE, anticorps PAS3, anticorps PASTICCINO 3, anticorps acetyl-CoA carboxylase 1, anticorps acc, anticorps fj43d01, anticorps im:7138837, anticorps si:ch211-199d18.1, anticorps wu:fj43d01, anticorps acetyl-CoA carboxylase alpha, anticorps acetyl-Coenzyme A carboxylase alpha, anticorps acetyl-CoA carboxylase 1, anticorps ACACA, anticorps Acaca, anticorps ACC1, anticorps acaca

Sujet:

Synonyms: ACAC, ACACA, ACACA, ACACA_HUMAN, ACC alpha, ACC-alpha, ACC1, ACC1, ACCA, Acetyl Coenzyme A, Biotin carboxylase, ACACA_MOUSE, Acetyl Coenzyme A carboxylase alpha, ACACA_RAT.

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCâ^ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACC alpha maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCâ^ is homologous to that of the ACCå, except for an additional peptide of about 150 amino acids at the N-terminus.

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, L'effet Warburg