Serotonin Receptor 2B anticorps (AA 1-100) (FITC)

N° du produit ABIN1394870

L’anticorps Lapin Polyclonal anti-Serotonin Receptor 2B a été validé pour WB, IF (cc) et IF (p). Il convient pour détecter Serotonin Receptor 2B dans des échantillons de Humain.

Aperçu rapide pour Serotonin Receptor 2B anticorps (AA 1-100) (FITC) (ABIN1394870)

Antigène: Serotonin Receptor 2B (HTR2B)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Serotonin Receptor 2B est conjugé à/à la FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Serotonin Receptor 2B anticorps (FITC)

Épitope: AA 1-100

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human 5HT2B Receptor/SR-2B

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Serotonin Receptor 2B

Antigène: Serotonin Receptor 2B (HTR2B)

Autre désignation: 5HT2B Receptor/SR-2B

Sujet:

Synonyms: 5 HT 2B, 5 HT 2B receptor, 5 HT2B, 5 HT2B, 5 hydroxytryptamine serotonin receptor 2B, 5 hydroxytryptamine serotonin receptor 2B G protein coupled, 5 hydroxytryptamine 2B receptor, 5 hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, 5-hydroxytryptamine receptor 2B, 5HT2B, 5HT2B_HUMAN, 5HT2F, Htr 2b, Htr2b, NP75 protein, SEROTONIN 5HT2B RECEPTOR, Serotonin receptor 2B, Stomach fundus serotonin receptor.

Background: Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.

Pathways: Signalistation JAK/STAT, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process