DPYSL2 anticorps (pSer518, pThr514) (Alexa Fluor 647)

N° du produit ABIN1398204

Détail du produit anti-DPYSL2 anticorps (Alexa Fluor 647)

Antigène: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Épitope: pSer518, pThr514

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPYSL2 est conjugé à/à la Alexa Fluor 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human CRMP2 around the phosphorylation site of Thr514+Ser518

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DPYSL2

Antigène: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Autre désignation: CRMP2+ (DPYSL2 Produits)

Synonymes: anticorps CRMP-2, anticorps CRMP2, anticorps DHPRP2, anticorps DRP-2, anticorps DRP2, anticorps N2A3, anticorps ULIP-2, anticorps ULIP2, anticorps TOAD-64, anticorps crmp2, anticorps dhprp2, anticorps drp-2, anticorps drp2, anticorps unc-33, anticorps unc33, anticorps dpysl2, anticorps CRMP 2, anticorps PCRMP 2, anticorps PCRMP-2, anticorps PCRMP2, anticorps PfCRMP 2, anticorps PfCRMP-2, anticorps AI851130, anticorps Crmp2, anticorps Musunc33, anticorps Ulip2, anticorps CRMP2A, anticorps dihydropyrimidinase like 2, anticorps dihydropyrimidinase-like 2, anticorps dihydropyrimidinase like 2 L homeolog, anticorps dihydropyrimidinase-like 2b, anticorps cysteine repeat modular protein 2, putative, anticorps DPYSL2, anticorps dpysl2.L, anticorps dpysl2b, anticorps PfCRMP2, anticorps dpysl2, anticorps Dpysl2

Sujet:

Synonyms: CRMP2 phospho T514 + S518, CRMP2 phospho T514+S518, CRMP-2phospho Thr514+S518, p-CRMP2Thr514+S518, CRMP2/Dpysl2DRP 2, Collapsin response mediator protein 2, Collapsin response mediator protein hCRMP 2, CRAM, CRMP 2, DHPRP 2, DHPRP2, Dihydr pyrimidinase 2, Dihydropyrimidinase 2, Dihydropyrimidinase like 2, Dihydropyrimidinase like 2 long form,Dihydropyrimidinase related protein 2, DPYL 2, DPYL2, DPYSL 2, DPYSL2, DRP 2, DRP2, Musunc 33, Musunc33, N2A3, TOAD 64, TOAD64, ULIP 2 protein, Ulip2.

Background: Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

ID gène: 1808

Pathways: Regulation of Cell Size