SARM1 anticorps (AA 340-380) (FITC)

N° du produit ABIN1400264

L’anticorps anti-SARM1 Polyclonal Lapin est utilisé pour la détection de SARM1 dans des échantillons de Humain. Il a été validé pour WB et IF (p).

Aperçu rapide pour SARM1 anticorps (AA 340-380) (FITC) (ABIN1400264)

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SARM1 est conjugé à/à la FITC

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-SARM1 anticorps (FITC)

Épitope: AA 340-380

Fonction: SARM1 Polyclonal Antibody, FITC Conjugated

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SARM1

Isotype: IgG

Information d'application

Indications d'application: WB(1:200-400), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur SARM1

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Autre désignation: SARM1

Sujet:

Synonyms: SARM, SAMD2, MyD88-5, Sterile alpha and TIR motif-containing protein 1, Sterile alpha and Armadillo repeat protein, Sterile alpha motif domain-containing protein 2, SAM domain-containing protein 2, Tir-1 homolog, SARM1, KIAA0524

Background: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

ID gène: 23098

UniProt: Q6SZW1

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades