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FEZF1 anticorps (AA 199-280) (Cy5.5)

FEZF1 Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5.5
N° du produit ABIN1409513
  • Antigène Voir toutes FEZF1 Anticorps
    FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))
    Épitope
    • 15
    • 14
    • 8
    • 4
    • 1
    • 1
    AA 199-280
    Reactivité
    • 36
    • 10
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 36
    Lapin
    Clonalité
    • 36
    Polyclonal
    Conjugué
    • 10
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FEZF1 est conjugé à/à la Cy5.5
    Application
    • 20
    • 18
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human ZNF312B
    Isotype
    IgG
    Top Product
    Discover our top product FEZF1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))
    Autre désignation
    ZNF312B/FEZF1 (FEZF1 Produits)
    Synonymes
    anticorps RGD1560480, anticorps fezf, anticorps znf312b, anticorps MGC145310, anticorps FEZ, anticorps ZNF312B, anticorps 3110069A13Rik, anticorps Fez, anticorps Zfp312-like, anticorps fez-like, anticorps fez, anticorps fezf2, anticorps wu:fc29c05, anticorps wu:fc89h05, anticorps zgc:153730, anticorps Fez family zinc finger 1, anticorps FEZ family zinc finger 1, anticorps Fez family zinc finger protein 1, anticorps FEZ family zinc finger 1 S homeolog, anticorps Fezf1, anticorps FEZF1, anticorps fezf1, anticorps Tsp_12536a, anticorps Tsp_12536, anticorps fezf1.S
    Sujet

    Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.

    Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.

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