ATM anticorps (pTyr170) (Cy5)

N° du produit ABIN1410754

Cet anticorps Lapin Polyclonal détecte spécifiquement ATM dans IF (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ATM anticorps (pTyr170) (Cy5) (ABIN1410754)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATM est conjugé à/à la Cy5

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-ATM anticorps (Cy5)

Épitope: pTyr170

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human ATM around the phosphorylation site of Tyr170 [SV(p-Y)FR]

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet:

Synonyms: ATM Tyr170, ATM Y170, p-ATM Tyr170, p-ATM Y170, A-T mutated, A-T mutated homolog, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT protein, AT1, ATA, Ataxia telangiectasia gene mutated in human beings, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog human, Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM_HUMAN, DKFZp781A0353, Human phosphatidylinositol 3 kinase homolog, MGC74674, Serine protein kinase ATM, Serine-protein kinase ATM, Serine/threonine-protein kinase ATM, T cell prolymphocytic leukemia, Tefu, TEL1, TEL1, telomere maintenance 1, homolog, TELO1, Telomere fusion protein, TPLL.

Background: ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).

Poids moléculaire: 370kDa

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus