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RNF19A anticorps (AA 621-720) (Cy5.5)

RNF19A Reactivité: Humain WB, IF (p), IF (cc) Hôte: Lapin Polyclonal Cy5.5
N° du produit ABIN1411157
  • Antigène Voir toutes RNF19A Anticorps
    RNF19A (Ring Finger Protein 19A (RNF19A))
    Épitope
    • 14
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 621-720
    Reactivité
    • 50
    • 13
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 48
    • 1
    • 1
    Lapin
    Clonalité
    • 49
    • 1
    Polyclonal
    Conjugué
    • 16
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RNF19A est conjugé à/à la Cy5.5
    Application
    • 36
    • 26
    • 15
    • 12
    • 12
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DORFIN/RNF19
    Isotype
    IgG
    Top Product
    Discover our top product RNF19A Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    RNF19A (Ring Finger Protein 19A (RNF19A))
    Autre désignation
    DORFIN/RNF19 (RNF19A Produits)
    Synonymes
    anticorps RNF19, anticorps RNF19A, anticorps AA032313, anticorps Dorfin, anticorps Rnf19, anticorps UIP117, anticorps Ubce7ip2, anticorps XYbp, anticorps ring finger protein 19A, RBR E3 ubiquitin protein ligase, anticorps ring finger protein 19A, anticorps RNF19A, anticorps Rnf19a
    Sujet

    Synonyms: Dorfin, Double ring finger protein, Double ring-finger protein, E3 ubiquitin-protein ligase RNF19A, p38, p38 protein, Ring finger protein 19, RING finger protein 19A, Ring IBR ring domain containing protein Dorfin, RN19A_HUMAN, RNF19, RNF19A, Ubce7ip2, UIP117, XYbp, AA032313, DKFZP566B1346.

    Background: Dorfin is a multi-pass membrane, RING-IBR type, E3 ubiquitin-protein ligase. It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system. Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates. Dorfin is responsible for ubiquitylating synphilin-1, CaSR and mutant variants of SOD-1, a protein at fault for familial ALS (amyotrophic lateral sclerosis). Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus. Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, such as Parkinson?s disease and ALS. This association with UBIs suggests that Dorfin plays an important role in the disease process.

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