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ARFGEF2 anticorps (AA 761-860) (Cy5.5)

ARFGEF2 Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5.5
N° du produit ABIN1411313
  • Antigène Voir toutes ARFGEF2 Anticorps
    ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
    Épitope
    • 14
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 761-860
    Reactivité
    • 43
    • 19
    • 12
    Humain
    Hôte
    • 43
    Lapin
    Clonalité
    • 43
    Polyclonal
    Conjugué
    • 12
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ARFGEF2 est conjugé à/à la Cy5.5
    Application
    • 23
    • 12
    • 12
    • 12
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human ARFGEF2/BIG2
    Isotype
    IgG
    Top Product
    Discover our top product ARFGEF2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
    Autre désignation
    ARFGEF2/BIG2 (ARFGEF2 Produits)
    Synonymes
    anticorps AI463430, anticorps AW493672, anticorps BIG2, anticorps E230011G24Rik, anticorps Big2, anticorps PVNH2, anticorps dJ1164I10.1, anticorps ADP ribosylation factor guanine nucleotide exchange factor 2, anticorps ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), anticorps ARFGEF2, anticorps Arfgef2
    Sujet

    Synonyms: ADP ribosylation factor guanine nucleotide exchange factor 2 brefeldin A inhibited, ADP ribosylation factor guanine nucleotide exchange factor 2, ARFGEF 2, ARFGEF2, ARFGEP2, BIG 2, BIG2, Brefeldin A inhibited 2, Brefeldin A inhibited GEP 2, Brefeldin A inhibited guanine nucleotide exchange protein 2, dJ1164I10.1, BIG2_HUMAN.

    Background: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects golgi structure, and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

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