Peroxiredoxin 2 anticorps (AA 131-198) (Cy5)
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- Antigène Voir toutes Peroxiredoxin 2 (PRDX2) Anticorps
- Peroxiredoxin 2 (PRDX2)
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Épitope
- AA 131-198
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Peroxiredoxin 2 est conjugé à/à la Cy5
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Application
- Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Rat
- Homologie
- Mouse,Dog,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Peroxiredoxin-2
- Isotype
- IgG
- Top Product
- Discover our top product PRDX2 Anticorps primaire
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- Indications d'application
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- Peroxiredoxin 2 (PRDX2)
- Autre désignation
- Peroxiredoxin 2 (PRDX2 Produits)
- Synonymes
- anticorps NKEF-B, anticorps NKEFB, anticorps PRP, anticorps PRX2, anticorps PRXII, anticorps PTX1, anticorps TDPX1, anticorps TPX1, anticorps TSA, anticorps AL022839, anticorps Band-8, anticorps NkefB, anticorps PrxII, anticorps TDX1, anticorps TPx, anticorps TPx-B, anticorps TR, anticorps Tdpx1, anticorps Torin, anticorps nkefb, anticorps prx-2, anticorps prx2, anticorps prxii, anticorps tdpx1, anticorps tpx1, anticorps peroxiredoxin 2, anticorps peroxiredoxin 2 L homeolog, anticorps PRDX2, anticorps Prdx2, anticorps prdx2.L
- Sujet
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Synonyms: MGC4104, Natural killer cell enhancing factor B, Natural killer cell-enhancing factor B, Natural Killer Enhancing Factor B, NKEF B, NKEF-B, NKEFB, Peroxiredoxin-2, PRDX 2, PRDX2, PRDX2_HUMAN, PRP, PRX2, PRXII, TDPX1, Thiol Specic Antioxidant 1, Thiol specic antioxidant protein, Thiol-specic antioxidant protein, Thioredoxin Dependent Peroxide Reductase 1, Thioredoxin Peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Torin, TPX1, TSA.
Background: Peroxiredoxin (Prx) is an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at the active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Peroxiredoxin 1 to 4 have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Peroxiredoxin 1. The active site cysteine(Cys51) is oxidized to cysteine sulfenic acid(Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from the other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress conditions, the sulfenic intermediate(Cys51-SOH) can be easily over oxidized to cysteine sulfinic acid(Cys-SO2H) or cysteine sulfonic acid(Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that over oxidized Prx can be reduced back to the active form during recovery after oxidative stress.
- ID gène
- 7001
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