PRPF3 anticorps

N° du produit ABIN1449201

Détail du produit anti-PRPF3 anticorps

Antigène: PRPF3 (PRP3 Pre-mRNA Processing Factor 3 Homolog (PRPF3))

Reactivité: Humain, Souris, Rat, Hamster

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PRPF3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificité: This antibody reacts with Prp3.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Hamster, Rat

Purification: Protein G agarose

Immunogène: Human recombinant full-length GSTPrp3

Clone: 4-00E-003

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur PRPF3

Antigène: PRPF3 (PRP3 Pre-mRNA Processing Factor 3 Homolog (PRPF3))

Autre désignation: PRPF3 (PRPF3 Produits)

Synonymes: anticorps HPRP3, anticorps HPRP3P, anticorps wu:fa11f05, anticorps PRPF3, anticorps PRP3, anticorps Prp3p, anticorps RP18, anticorps SNRNP90, anticorps 3632413F13Rik, anticorps PRP3 pre-mRNA processing factor 3 homolog (yeast), anticorps pre-mRNA processing factor 3, anticorps pre-mRNA processing factor 3 S homeolog, anticorps PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae), anticorps prpf3, anticorps PRPF3, anticorps prpf3.S, anticorps Prpf3

Sujet: Retinitis pigmentosa (RP) is an inheritable disease characterized by progressive retinal degeneration and loss of rod photoreceptor cells, leading to total blindness. Recently three genes responsible for autosomal dominant RP (HPRP3, PRPF31, and PRPC8) have been identified as the human orthologues of the yeast genes PRP3, PRP31, and PRP8, respectively. The removal of introns from nuclear pre-mRNAs occurs on spliceosomes, which consist of 4 small nuclear ribonucleoprotein (snRNP) particles and a number of transiently associated splicing factors. All three PRP (pre-mRNA processing factor) genes are involved in the function of the U4/U6,U5 tri-snRNP, the spliceosome component required for the transition to a catalytically active state. In mammals, the 63 kDa HPRP3 is thought to recruit HPRP4 to the U4/U6 snRNP. In yeast, PRP3 and PRP4 genetically interact, and physical interactions between Prp3p and Prp4p proteins are required for association of Prp3p and Prp4p with U4/U6.Synonyms: HPRP3, PRP3, Pre-mRNA-splicing factor 3, U4/U6 small nuclear ribonucleoprotein Prp3, U4/U6 snRNP 90 kDa protein

Poids moléculaire: 80 kDa

ID gène: 9129

NCBI Accession: NP_004689

UniProt: O43395