DBN1 anticorps (N-Term) (PE)

N° du produit ABIN1449752

Détail du produit anti-DBN1 anticorps (PE)

Antigène: DBN1 (Drebrin 1 (DBN1))

Épitope: AA 1-326, N-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DBN1 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Size-Exclusion Chromatography and adjusted for direct use. No reconstitution is necessary

Immunogène: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326).

Clone: DBN-N-03

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This products is photosensitive and should be protected from light.

Détails sur DBN1

Antigène: DBN1 (Drebrin 1 (DBN1))

Autre désignation: Drebrin (DBN1 Produits)

Synonymes: anticorps D0S117E, anticorps DBN1, anticorps LOC733967, anticorps drebrin 1, anticorps drebrin 1 S homeolog, anticorps DBN1, anticorps Dbn1, anticorps dbn1.S, anticorps dbn1

Sujet: Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.Synonyms: D0S117E, DBN-1, DBN1, DKFZp434D064, Developmentally-regulated brain protein, drebrin 1

ID gène: 1627

NCBI Accession: NP_004386

Pathways: Maintenance of Protein Location