CEP290 anticorps (Internal Region)

N° du produit ABIN1449753

Détail du produit anti-CEP290 anticorps

Antigène: CEP290 (Centrosomal Protein 290kDa (CEP290))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp CEP290 est non-conjugé

Application: Immunofluorescence (IF)

Séquence: C-RNSKHLKQQQ YRAEN

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_079390.3. Genename: CEP290

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CEP290

Antigène: CEP290 (Centrosomal Protein 290kDa (CEP290))

Autre désignation: CEP290 (CEP290 Produits)

Synonymes: anticorps ct87, anticorps mks4, anticorps rd16, anticorps bbs14, anticorps jbts5, anticorps jbts6, anticorps lca10, anticorps nphp6, anticorps slsn6, anticorps sh11ag, anticorps MGC81471, anticorps 3h11ag, anticorps RGD1311640, anticorps BC004690, anticorps Nphp6, anticorps b2b1454Clo, anticorps b2b1752Clo, anticorps im:7145703, anticorps im:7147820, anticorps 3H11Ag, anticorps BBS14, anticorps CT87, anticorps JBTS5, anticorps LCA10, anticorps MKS4, anticorps NPHP6, anticorps POC3, anticorps SLSN6, anticorps centrosomal protein 290, anticorps centrosomal protein 290 L homeolog, anticorps centrosomal protein 290kDa, anticorps CEP290, anticorps cep290.L, anticorps cep290, anticorps Cep290

Sujet: CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: CT87, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, KIAA0373, NPHP6, Nephrocystin-6, Tumor antigen se2-2, se2-2

ID gène: 80184

NCBI Accession: NP_079390

Pathways: cAMP Metabolic Process, M Phase