TACI anticorps (PE)

N° du produit ABIN1504150

Détail du produit anti-TACI anticorps (PE)

Antigène: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TACI est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: This antibody reacts with CD267 antigen. Clone 11H3 has an agonistic activity and it doesn't block binding of BAFF to TACI.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Clone: 11H3

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 50 tests in 1 mLvolume of PBS containing 1 % BSA and 0.09 % NaN3

Détails sur TACI

Antigène: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Autre désignation: CD267 / TACI (TNFRSF13B Produits)

Synonymes: anticorps CD267, anticorps CVID, anticorps CVID2, anticorps RYZN, anticorps TACI, anticorps TNFRSF14B, anticorps TNFRSF13B, anticorps 1200009E08Rik, anticorps Taci, anticorps TNF receptor superfamily member 13B, anticorps tumor necrosis factor receptor superfamily, member 13b, anticorps TNFRSF13B, anticorps Tnfrsf13b

Sujet: CD267, also known as TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) or TNFRSF13B, is a member of the tumor necrosis factor (TNF) receptor family that serves as a receptor for B-cell activating factor of the TNF family (BAFF/CD257) and as a proliferation-inducing ligand (APRIL/CD256). BAFF and APRIL bind both TACI and BCMA (B cell maturation Ag/CD269), with BAFF additionally and exclusivel y binding the BAFF receptor (BAFF-R/CD268) while APRIL can also bind to heparin sulfate proteoglycan s (HSPG). TACI is expressed on B cells and activated T cells. BC MA is exclusively expressed on B cells, whereas BAFF-R is expressed mainly on B cells but also on T cells. It is reported that mutations of CD267/TACI are showed in patients with IgA deficiency and common variable immunodeficiency (CVID). Sakurai et al ., reported that TACI positively regulated APRIL-induced IgA production in collaboration with HSPG and TACI negatively regulated BAFF-induced B-cell proliferation and production of IgA and IgG.Synonyms: TNFRSF13B, Transmembrane activator and CAML interactor, Tumor necrosis factor receptor superfamily member 13B

ID gène: 23495