ADAM17 anticorps (ADAM Metallopeptidase Domain 17) (AA 701-750)

Details for Product anti-ADAM17 Antibody No. ABIN1531481
Antigène
  • ADAM18
  • CD156B
  • CSVP
  • NISBD
  • TACE
  • CD156b
  • Tace
  • adam17
  • si:dkey-81b15.2
  • adam18
  • cd156b
  • csvp
  • tace
  • fc20b01
  • wu:fc20b01
  • zgc:63886
  • ADAM metallopeptidase domain 17
  • a disintegrin and metallopeptidase domain 17
  • ADAM metallopeptidase domain 17b
  • ADAM metallopeptidase domain 17 L homeolog
  • ADAM metallopeptidase domain 17a
  • ADAM17
  • Adam17
  • adam17b
  • adam17.L
  • adam17a
Épitope
AA 701-750, pThr735
63
18
16
11
10
9
8
8
7
6
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
243
95
86
2
2
1
1
1
1
1
Hôte
Lapin
207
22
21
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp ADAM17 est non-conjugé
14
10
7
6
6
5
4
4
4
4
4
4
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
195
120
45
39
25
14
11
11
10
7
5
3
2
1
1
1
Options
Immunogène The antiserum was produced against synthesized peptide derived from human ADAM 17 around the phosphorylation site of Thr735.
Isotype IgG
Specificité

ADAM 17 (Phospho-Thr735) Antibody detects endogenous levels of ADAM 17 only when phosphorylated at Thr735.

PhosphorylationH:T735 M:T735 R:T735

Purification The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Pureté > 95 %
Plasmids, Primers & others Plasmids, Primers & others ADAM17 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation ADAM 17 (ADAM17 Antibody Extrait)
Sujet

Synonyms: ADA17, ADAM 17, CD156b antigen, CSVP, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme, a disintegrin and metalloproteinase domain 17, snake venom-like protease

NCBI Gene Symbol: ADAM17

Poids moléculaire 93 kDa
ID gène 6868
OMIM 603639
UniProt P78536
Pathways Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
Indications d'application WB: 1:500~1:1000 ELISA: 1:20000
Commentaires

Unigene-Number: Hs.404914 (NCBI Gene Symbol: ADAM17)

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Stable at -20°C for at least 1 year.
Date de péremption 12 months
Images (Fournisseur)
Western Blotting (WB) image for anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 701-750), (pThr735) antibody (ABIN1531481) Western blot analysis of extracts from K562 cells treated with UV 5', using ADAM 17 (...
Produit citée dans: Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: "Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease." dans: Neurobiology of disease, Vol. 74, pp. 32-40, 2015 (PubMed).

Background publications Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." dans: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: "Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ..." dans: Nature, Vol. 385, Issue 6618, pp. 733-6, 1997 (PubMed).

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