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ADAM17 anticorps

ADAM17 Reactivité: Humain, Rat, Souris WB, FACS, IF (cc) Hôte: Lapin Monoclonal 9E7 unconjugated
N° du produit ABIN5557408
  • Antigène Voir toutes ADAM17 Anticorps
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Reactivité
    • 114
    • 53
    • 51
    • 4
    • 4
    • 4
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 99
    • 13
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 92
    • 24
    Monoclonal
    Conjugué
    • 53
    • 11
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADAM17 est non-conjugé
    Application
    • 86
    • 53
    • 39
    • 14
    • 14
    • 14
    • 12
    • 11
    • 10
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    Recombinant human ADAM17 protein, around 700-824aa.
    Clone
    9E7
    Isotype
    IgG
    Top Product
    Discover our top product ADAM17 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    FCM 1:20-100
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Six, Debaene, Van den Hauwe, De Rycke, Gardiner, Compernolle, Feys: "GPIbα shedding in platelets is controlled by strict intracellular containment of both enzyme and substrate." dans: Journal of thrombosis and haemostasis : JTH, (2023) (PubMed).

  • Antigène
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Autre désignation
    ADAM17 (ADAM17 Produits)
    Synonymes
    anticorps ADAM18, anticorps CD156B, anticorps CSVP, anticorps NISBD, anticorps TACE, anticorps CD156b, anticorps Tace, anticorps adam17, anticorps si:dkey-81b15.2, anticorps adam18, anticorps cd156b, anticorps csvp, anticorps tace, anticorps fc20b01, anticorps wu:fc20b01, anticorps zgc:63886, anticorps ADAM metallopeptidase domain 17, anticorps a disintegrin and metallopeptidase domain 17, anticorps ADAM metallopeptidase domain 17b, anticorps ADAM metallopeptidase domain 17 L homeolog, anticorps ADAM metallopeptidase domain 17a, anticorps ADAM17, anticorps Adam17, anticorps adam17b, anticorps adam17.L, anticorps adam17a
    Sujet

    Synonyms: Disintegrin and metalloproteinase domain-containing protein 17, ADAM metallopeptidase domain 17, CSVP, TACE, NISBD, CD156B, NISBD1, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, Tumor Necrosis Factor Alpha Converting Enzyme.

    Background: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

    ID gène
    6868
    UniProt
    P78536
    Pathways
    Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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