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ADAM17 anticorps (pThr735)

ADAM17 Reactivité: Humain, Rat, Souris WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6255732
  • Antigène Voir toutes ADAM17 Anticorps
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Épitope
    • 16
    • 13
    • 12
    • 8
    • 8
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr735
    Reactivité
    • 114
    • 53
    • 51
    • 4
    • 4
    • 4
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 99
    • 13
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 91
    • 25
    Polyclonal
    Conjugué
    • 53
    • 11
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADAM17 est non-conjugé
    Application
    • 86
    • 52
    • 40
    • 15
    • 14
    • 13
    • 11
    • 11
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Phospho-ADAM 17 (Thr735) Antibody detects endogenous levels of ADAM 17 only when phosphorylated at Threonine 735.
    Homologie
    Bovine,Horse,Sheep,Dog
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human ADAM 17 around the phosphorylation site of Thr735.
    Isotype
    IgG
    Top Product
    Discover our top product ADAM17 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
    Autre désignation
    ADAM17 (ADAM17 Produits)
    Synonymes
    anticorps ADAM18, anticorps CD156B, anticorps CSVP, anticorps NISBD, anticorps TACE, anticorps CD156b, anticorps Tace, anticorps adam17, anticorps si:dkey-81b15.2, anticorps adam18, anticorps cd156b, anticorps csvp, anticorps tace, anticorps fc20b01, anticorps wu:fc20b01, anticorps zgc:63886, anticorps ADAM metallopeptidase domain 17, anticorps a disintegrin and metallopeptidase domain 17, anticorps ADAM metallopeptidase domain 17b, anticorps ADAM metallopeptidase domain 17 L homeolog, anticorps ADAM metallopeptidase domain 17a, anticorps ADAM17, anticorps Adam17, anticorps adam17b, anticorps adam17.L, anticorps adam17a
    Sujet

    Description: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

    Gene: ADAM17

    Poids moléculaire
    93kDa
    ID gène
    6868
    UniProt
    P78536
    Pathways
    Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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