WISP2 anticorps

N° du produit ABIN1574004

Détail du produit anti-WISP2 anticorps

Antigène: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Reactivité: Veuillez nous consulter SVP

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp WISP2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Protein A affinity column

Immunogène: WISP2 full length recombinant protein with GST tag

Clone: 5D11E11

Isotype: IgG

Information d'application

Indications d'application: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

ELISA: 0.05-0.2 µg/mL
Western blot: 0.1-1.0 µg/mL
Other applications: user-optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Détails sur WISP2

Antigène: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Autre désignation: WISP2 (WISP2 Produits)

Synonymes: anticorps MGC84196, anticorps WISP2, anticorps ccn5, anticorps CCN5, anticorps CT58, anticorps CTGF-L, anticorps Ccn5, anticorps Crgr4, anticorps Ctgfl, anticorps Rcop1, anticorps WNT1 inducible signaling pathway protein 2, anticorps WNT1 inducible signaling pathway protein 2 S homeolog, anticorps WISP2, anticorps wisp2.S, anticorps wisp2, anticorps Wisp2

Sujet: WISP-2 is a member of the connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (nov) (CCN) family and is upregulated in the mouse mammary epithelial cell line C57MG transformed by Wnt-1 and in several non-invasive human breast tumor cell lines. WISP-2 expression is enhanced by important modulators of human breast cancer cell proliferation such as estrogen, progesterone and epidermal growth factor (EGF) in MCF-7 cells. These effects, inhibited by appropriate antagonists, indicate that steroids and growth factor-induced upregulation of WISP-2 may be mediated through receptors. WISP2 gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Pathways: Signalisation WNT, Growth Factor Binding