DDX60 anticorps

N° du produit ABIN1587945

Détail du produit anti-DDX60 anticorps

Antigène: DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 (DDX60))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDX60 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificité: At least three isoforms of DDX60 are known to exist, this antibody will detect all three isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogène: DDX60 antibody was raised against a 17 amino acid synthetic peptide near the center of human DDX60.

Isotype: IgG

Information d'application

Indications d'application: DDX60 antibody can be used for detection of DDX60 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Commentaires:

(IN) DEAD box protein 60

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C

Stockage commentaire: DDX60 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Date de péremption: 12 months

Détails sur DDX60

Antigène: DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 (DDX60))

Autre désignation: DDX60 (DDX60 Produits)

Synonymes: anticorps 9830118M07, anticorps RGD1560014, anticorps DExD/H-box helicase 60, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 60, anticorps DEXD/H-box helicase 60, anticorps DDX60, anticorps Ddx60

Sujet: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.

Poids moléculaire: 188 kDa

ID gène: 55601

NCBI Accession: NP_060101