SLC7A5 anticorps (AA 1-125)

N° du produit ABIN1682793

Détail du produit anti-SLC7A5 anticorps

Antigène: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Épitope: AA 1-125

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC7A5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV GTIIGSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM LEVYG

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human SLC7A5 (NP_003477.4).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-SLC7A5 (ABIN1682793)

Hu, Nie, Chen, Xie, Fan, Wang, Long, Yan, Zhong, Yan: "Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells." dans: The international journal of biochemistry & cell biology, Vol. 89, pp. 42-56, (2017) (PubMed).

Détails sur SLC7A5

Antigène: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Autre désignation: SLC7A5 (SLC7A5 Produits)

Synonymes: anticorps 4F2LC, anticorps CD98, anticorps D16S469E, anticorps E16, anticorps LAT1, anticorps MPE16, anticorps hLAT1, anticorps D0H16S474E, anticorps TA1, anticorps JHI-21, anticorps SLC7A5, anticorps LAT-1, anticorps slc7a5a, anticorps 4F2, anticorps 4F2HC, anticorps AI314110, anticorps Cd98, anticorps Ly-10, anticorps Ly-m10, anticorps Ly10, anticorps Mdu1, anticorps Mgp-2hc, anticorps NACAE, anticorps solute carrier family 7 member 5, anticorps solute carrier family 7 (cationic amino acid transporter, y+ system), member 5, anticorps solute carrier family 7 (amino acid transporter light chain, L system), member 5, anticorps solute carrier family 7 member 5 S homeolog, anticorps solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, anticorps SLC7A5, anticorps Slc7a5, anticorps slc7a5.S, anticorps Slc3a2

Sujet: The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity. May act as the major transporter of tyrosine in fibroblasts (Probable. May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity. Can mediate the transport of thyroid hormones triiodothyronine (T3 and thyroxine (T4 across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO across the membrane.,SLC7A5,4F2LC,CD98,D16S469E,E16,LAT1,MPE16,hLAT1,Cancer,Signal Transduction,Endocrine & Metabolism,SLC7A5

Poids moléculaire: 55 kDa

ID gène: 8140

UniProt: Q01650