SLC7A5 anticorps (C-Term)

N° du produit ABIN6265149

Détail du produit anti-SLC7A5 anticorps

Antigène: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC7A5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: SLC7A5 Antibody detects endogenous levels of total SLC7A5.

Homologie: Pig,Zebrafish,Bovine,Sheep,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SLC7A5, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SLC7A5

Antigène: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Autre désignation: SLC7A5 (SLC7A5 Produits)

Synonymes: anticorps 4F2LC, anticorps CD98, anticorps D16S469E, anticorps E16, anticorps LAT1, anticorps MPE16, anticorps hLAT1, anticorps D0H16S474E, anticorps TA1, anticorps JHI-21, anticorps SLC7A5, anticorps LAT-1, anticorps slc7a5a, anticorps 4F2, anticorps 4F2HC, anticorps AI314110, anticorps Cd98, anticorps Ly-10, anticorps Ly-m10, anticorps Ly10, anticorps Mdu1, anticorps Mgp-2hc, anticorps NACAE, anticorps solute carrier family 7 member 5, anticorps solute carrier family 7 (cationic amino acid transporter, y+ system), member 5, anticorps solute carrier family 7 (amino acid transporter light chain, L system), member 5, anticorps solute carrier family 7 member 5 S homeolog, anticorps solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, anticorps SLC7A5, anticorps Slc7a5, anticorps slc7a5.S, anticorps Slc3a2

Sujet:

Description: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

Gene: SLC7A5

Poids moléculaire: 55 kDa

ID gène: 8140

UniProt: Q01650