ATM anticorps (pSer794) (Biotin)

N° du produit ABIN1700101

Cet anticorps Lapin Polyclonal détecte spécifiquement ATM dans ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour ATM anticorps (pSer794) (Biotin) (ABIN1700101)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATM est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ATM anticorps (Biotin)

Épitope: pSer794

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human ATM around the phosphorylation site of Ser794

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet:

Synonyms: ATM Ser794, ATM phospho S794, p-ATM Ser794, p-ATM S794, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT protein,AT1,ATA,Ataxia telangiectasia gene mutated in human beings, Ataxia telangiectasia mutated, ATC, ATDC, ATE, ATM, Human phosphatidylinositol 3 kinase homolog, Serine protein kinase ATM, T cell prolymphocytic leukemia, TEL1, TPLL, ATM_HUMAN.

Background: ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).

ID gène: 472

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus