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ARFGEF1 anticorps (AA 1-200) (HRP)

ARFGEF1 Reactivité: Souris WB, IHC (p), IHC (fro) Hôte: Lapin Polyclonal HRP
N° du produit ABIN1711628
  • Antigène Voir toutes ARFGEF1 Anticorps
    ARFGEF1 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1))
    Épitope
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-200
    Reactivité
    • 18
    • 16
    • 11
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 29
    • 1
    Lapin
    Clonalité
    • 29
    • 1
    Polyclonal
    Conjugué
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ARFGEF1 est conjugé à/à la HRP
    Application
    • 13
    • 13
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human BIG1/ARFGEF1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C/-80 °C
    Stockage commentaire
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Date de péremption
    12 months
  • Antigène
    ARFGEF1 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1))
    Autre désignation
    BIG1/ARFGEF1 (ARFGEF1 Produits)
    Synonymes
    anticorps ARFGEF1, anticorps ARFGEP1, anticorps BIG1, anticorps P200, anticorps D130059B05Rik, anticorps D730028O18Rik, anticorps RGD1560793, anticorps ADP ribosylation factor guanine nucleotide exchange factor 1, anticorps brefeldin A-inhibited guanine nucleotide-exchange protein 1, anticorps ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited), anticorps ARFGEF1, anticorps CpipJ_CPIJ004831, anticorps Arfgef1
    Sujet

    Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

    Subcellular location: Cytoplasm, Nucleus, Cell membrane

    Synonyms: ADPribosylation factor guanine nucleotide exchange factor 1brefeldin A inhibited, ARFGEF1, ARFGEP1, Brefeldin A inhibited GEP 1, Brefeldin A inhibited guanine nucleotide exchange protein 1, p200 ARF GEP1, p200 ARF guanine nucleotide exchange factor, BIG1_HUMAN.

    ID gène
    10565
    Pathways
    Regulation of Actin Filament Polymerization, Regulation of Carbohydrate Metabolic Process
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