ATM anticorps (full length)

N° du produit ABIN1721458

Cet anticorps Souris Monoclonal détecte spécifiquement ATM dans WB, IHC, ELISA, IF, IP, FACS, ICC et ChIP. Il présente une réactivité envers Humain, Souris, Rat et Singe.

Aperçu rapide pour ATM anticorps (full length) (ABIN1721458)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)

Clone: 2C1

Détail du produit anti-ATM anticorps

Épitope: AA 2577-3056, full length

Specificité: Reacts with human ATM. Cross-reacts with mouse, rat and monkey protein.

Purification: Purified

Immunogène: GST fusion protein expressed in E. coli corresponding to aa 2577- 3056 of full-length ATM.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB1:500 - 1:3000 IHC-P5 μg/mL IP1 - 10 μg/mL.

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Dilute in PBS or medium that is identical to that used in the assay system.

Stock: -20 °C/-80 °C

Stockage commentaire: Stable for at least one year at -20°C or -70°C. Avoid multiple freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: ATM is a 370 kD nuclear phosphoprotein,which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.

Serine-protein kinase ATM Ataxia telangiectasia mutated, A-T mutated gene name: ATM AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1

ID gène: 472

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus