PINK1 anticorps (AA 258-274)

N° du produit ABIN1738112

Détail du produit anti-PINK1 anticorps

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Épitope: AA 258-274

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINK1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Reacts with human PINK1.

Purification: Purified

Immunogène: Synthetic peptide corresponding to amino acids 258-274 (YRKSKRGPKQLAPHPNI) of human PINK1 conjugated to KLH.

Isotype: IgG

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB 1:500 dilution

Positive control: Transfected cell lines

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.4,

Conseil sur la manipulation: Dilute in PBS or medium which is identical to that used in the assay system.

Stock: 4 °C/-20 °C

Stockage commentaire: Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.

Date de péremption: 6 months

Détails sur PINK1

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Autre désignation: PINK1 (PINK1 Produits)

Synonymes: anticorps BEST:GH23468, anticorps CG4523, anticorps Dmel\\CG4523, anticorps PINK, anticorps PINK1, anticorps dPINK1, anticorps dPink1, anticorps pink1, anticorps wu:fc39e12, anticorps zgc:101729, anticorps BRPK, anticorps PARK6, anticorps 1190006F07Rik, anticorps AU042772, anticorps AW557854, anticorps mFLJ00387, anticorps PTEN-induced putative kinase 1, anticorps PTEN induced putative kinase 1, anticorps Pink1, anticorps PINK1, anticorps pink1

Sujet: PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2.

Serine/threonine-protein kinase PINK1, mitochondrial BRPK PTEN-induced putative kinase protein 1 Gene name: PINK1

ID gène: 65018

UniProt: Q9BXM7

Pathways: Autophagy