CSF2RA anticorps (C-Term)

N° du produit ABIN1881231

Détail du produit anti-CSF2RA anticorps

Antigène: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Épitope: AA 366-394, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSF2RA est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CSF2RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-394 amino acids from the C-terminal region of human CSF2RA.

Clone: RB40748

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CSF2RA (ABIN1881231)

Mirza, Walker, Chen, Murphy, Young: "The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation." dans: The Biochemical journal, Vol. 426, Issue 3, pp. 307-17, (2010) (PubMed).

Martinez-Moczygemba, Doan, Elidemir, Fan, Cheung, Lei, Moore, Tavana, Lewis, Zhu, Muzny, Gibbs, Huston: "Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1." dans: The Journal of experimental medicine, Vol. 205, Issue 12, pp. 2711-6, (2008) (PubMed).

Hansen, Hercus, McClure, Stomski, Dottore, Powell, Ramshaw, Woodcock, Xu, Guthridge, McKinstry, Lopez, Parker: "The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation." dans: Cell, Vol. 134, Issue 3, pp. 496-507, (2008) (PubMed).

Détails sur CSF2RA

Antigène: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Autre désignation: CSF2RA (CSF2RA Produits)

Synonymes: anticorps CD116, anticorps CDw116, anticorps CSF2R, anticorps CSF2RAX, anticorps CSF2RAY, anticorps CSF2RX, anticorps CSF2RY, anticorps GM-CSF-R-alpha, anticorps GMCSFR, anticorps GMR, anticorps SMDP4, anticorps Csfgmra, anticorps GM-CSF-Ra, anticorps GM-CSFR, anticorps colony stimulating factor 2 receptor, alpha, anticorps colony stimulating factor 2 receptor alpha subunit, anticorps colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage), anticorps CSF2RA, anticorps Csf2ra

Sujet: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.

Poids moléculaire: 46207

NCBI Accession: NP_001155001, NP_001155002, NP_001155003, NP_001155004, NP_006131, NP_758448, NP_758449, NP_758450, NP_758452

UniProt: P15509

Pathways: Signalistation JAK/STAT