CSF2RA anticorps

N° du produit ABIN1981902

Détail du produit anti-CSF2RA anticorps

Antigène: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CSF2RA est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Cytometry by Time of Flight (CyTOF)

Specificité: The mouse monoclonal antibody 4H1 recognizes an extracellular epitope of human CD116, the GM-CSF receptor alpha subunit (approx. 80 kDa) expressed e.g. by neutrophils, eosinophils, monocytes and macrophages.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: CD116-transfected COS cells

Clone: 4H1

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze. Do not use after expiration date stamped on vial label.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CSF2RA (ABIN1981902)

Schwarzmaier, Foell, Weinhage, Varga, Däbritz: "Peripheral monocyte functions and activation in patients with quiescent Crohn's disease." dans: PLoS ONE, Vol. 8, Issue 4, pp. e62761, (2013) (PubMed).

Koba, Haruta, Matsunaga, Matsumura, Haga, Sasaki, Ikeda, Takamatsu, Nishimura, Senju: "Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-? against peritoneally disseminated cancer in xenograft models." dans: PLoS ONE, Vol. 8, Issue 6, pp. e67567, (2013) (PubMed).

Huntington, Legrand, Alves, Jaron, Weijer, Plet, Corcuff, Mortier, Jacques, Spits, Di Santo: "IL-15 trans-presentation promotes human NK cell development and differentiation in vivo." dans: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 25-34, (2009) (PubMed).

Détails sur CSF2RA

Antigène: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Autre désignation: CD116 (CSF2RA Produits)

Synonymes: anticorps CD116, anticorps CDw116, anticorps CSF2R, anticorps CSF2RAX, anticorps CSF2RAY, anticorps CSF2RX, anticorps CSF2RY, anticorps GM-CSF-R-alpha, anticorps GMCSFR, anticorps GMR, anticorps SMDP4, anticorps Csfgmra, anticorps GM-CSF-Ra, anticorps GM-CSFR, anticorps colony stimulating factor 2 receptor, alpha, anticorps colony stimulating factor 2 receptor alpha subunit, anticorps colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage), anticorps CSF2RA, anticorps Csf2ra

Sujet: Colony stimulating factor 2 receptor alpha subunit,CD116 (GM-CSF R alpha) is the low affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF). CD116 heterodimerizes with CD131, the common beta chain subunit shared with IL-3 and IL5- receptors, to form the high affinity GM-CSF receptor. CD116 is expressed by myeloid cells including macrophages, neutrophils, eosinophils, dendritic cells, and their precursors, as well as on endothelial cells. It is being used as a specific marker of myeloid leukemias.,CSF2RA, GMR, CSF2R, SMDP4, GMCSFR

ID gène: 1438

UniProt: P15509

Pathways: Signalistation JAK/STAT