HLA-DQA2 anticorps (AA 39-66)

N° du produit ABIN1881421

Détail du produit anti-HLA-DQA2 anticorps

Antigène: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Épitope: AA 39-66

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DQA2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HLA-DQA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human HLA-DQA2.

Clone: RB42054

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-HLA-DQA2 (ABIN1881421)

Hor, Kutalik, Dauvilliers, Valsesia, Lammers, Donjacour, Iranzo, Santamaria, Peraita Adrados, Vicario, Overeem, Arnulf, Theodorou, Jennum, Knudsen, Bassetti: "Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy." dans: Nature genetics, Vol. 42, Issue 9, pp. 786-9, (2010) (PubMed).

Petukhova, Duvic, Hordinsky, Norris, Price, Shimomura, Kim, Singh, Lee, Chen, Meyer, Paus, Jahoda, Amos, Gregersen, Christiano: "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity." dans: Nature, Vol. 466, Issue 7302, pp. 113-7, (2010) (PubMed).

Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." dans: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." dans: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Détails sur HLA-DQA2

Antigène: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Autre désignation: HLA-DQA2 (HLA-DQA2 Produits)

Synonymes: anticorps DX-ALPHA, anticorps HLA-DXA, anticorps major histocompatibility complex, class II, DQ alpha 2, anticorps HLA-DQA2

Sujet: This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq].

Poids moléculaire: 28033

NCBI Accession: NP_064440

UniProt: P01906

Pathways: TCR Signaling