Kv1.4 anticorps (C-Term)

N° du produit ABIN1881472

Détail du produit anti-Kv1.4 anticorps

Antigène: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Épitope: AA 591-619, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kv1.4 est non-conjugé

Application: Western Blotting (WB)

Homologie: B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.

Clone: RB41939

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Kv1.4 (ABIN1881472)

Schwetz, Norring, Bennett: "N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating." dans: Biochimica et biophysica acta, Vol. 1798, Issue 3, pp. 367-75, (2010) (PubMed).

Lee, Lee, Choi, Yoon, Pyo, Shin, Choi, Lim, Rhim, Won, Lim, Choe, Kim, Kim, Nah: "Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue." dans: Molecular pharmacology, Vol. 73, Issue 3, pp. 619-26, (2008) (PubMed).

Mckeown, Burnham, Hodson, Jones et al.: "Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in..." dans: The Journal of biological chemistry, Vol. 283, Issue 44, pp. 30421-32, (2008) (PubMed).

Détails sur Kv1.4

Antigène: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Autre désignation: KCNA4 (KCNA4 Produits)

Synonymes: anticorps KV1.4, anticorps KCNA4, anticorps Kv1.4, anticorps DKFZp459N0126, anticorps KCHAN, anticorps Kv4, anticorps RHK1, anticorps RK3, anticorps HBK4, anticorps HK1, anticorps HPCN2, anticorps HUKII, anticorps KCNA4L, anticorps KCNA8, anticorps PCN2, anticorps potassium voltage-gated channel subfamily A member 4, anticorps potassium voltage-gated channel subfamily A member 4 S homeolog, anticorps potassium voltage-gated channel, shaker-related subfamily, member 4, anticorps KCNA4, anticorps LOC100622932, anticorps kcna4.S, anticorps Kcna4

Sujet: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Poids moléculaire: 73257

NCBI Accession: NP_002224

UniProt: P22459