p53 anticorps (pSer9)

N° du produit ABIN1881624

Détail du produit anti-p53 anticorps

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Épitope: pSer9

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p53 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Dot Blot (DB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This P53 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S9 of human P53.

Clone: RB7893

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-p53 (ABIN1881624)

Blanchette, Cheng, Yan, Ketner, Ornelles, Dobner, Conaway, Conaway, Branton: "Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53." dans: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9619-29, (2004) (PubMed).

Adachi, Toyota, Sasaki, Yamashita, Ishida, Ohe-Toyota, Maruyama, Hinoda, Saito, Imai, Kudo, Tokino: "Identification of SCN3B as a novel p53-inducible proapoptotic gene." dans: Oncogene, Vol. 23, Issue 47, pp. 7791-8, (2004) (PubMed).

Zhang, Wang, Chen, Zhang, Cheng, Heng, Wu, Shen: "Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells." dans: The Journal of biological chemistry, Vol. 279, Issue 41, pp. 42545-51, (2004) (PubMed).

Anazawa, Arakawa, Nakagawa, Nakamura: "Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway." dans: Oncogene, Vol. 23, Issue 46, pp. 7621-7, (2004) (PubMed).

Montagnoli, Tenca, Sola, Carpani, Brotherton, Albanese, Santocanale: "Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells." dans: Cancer research, Vol. 64, Issue 19, pp. 7110-6, (2004) (PubMed).

Détails sur p53

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: P53 (TP53 Produits)

Synonymes: anticorps BCC7, anticorps LFS1, anticorps P53, anticorps TRP53, anticorps p53, anticorps Trp53, anticorps brp53, anticorps drp53, anticorps etID22686.5, anticorps fb40d06, anticorps wu:fb40d06, anticorps zgc:111919, anticorps Tp53, anticorps bbl, anticorps bfy, anticorps bhy, anticorps p44, anticorps tp53, anticorps Xp53, anticorps TP53, anticorps tumor protein p53, anticorps cellular tumor antigen p53, anticorps transformation related protein 53, anticorps tumor protein p53 L homeolog, anticorps TP53, anticorps CpipJ_CPIJ002758, anticorps Tp53, anticorps tp53, anticorps Trp53, anticorps tp53.L

Sujet: Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.

Poids moléculaire: 43653

NCBI Accession: NP_000537, NP_001119584, NP_001119585, NP_001119586, NP_001119587, NP_001119588, NP_001119589, NP_001119590, NP_001263624, NP_001263625, NP_001263626, NP_001263627, NP_001263628, NP_00126

UniProt: P04637

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg