PARP1 anticorps (pSer373)

N° du produit ABIN1881626

L’anticorps Lapin Polyclonal anti-PARP1 a été validé pour DB. Il convient pour détecter PARP1 dans des échantillons de Rat. Il y a 5+ publications disponibles.

Aperçu rapide pour PARP1 anticorps (pSer373) (ABIN1881626)

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP1 est non-conjugé

Application: Dot Blot (DB)

Clone: RB40136

Détail du produit anti-PARP1 anticorps

Épitope: pSer373

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This rat PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S373 of rat PARP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PARP1 (ABIN1881626)

Beneke, Scherr, Ponath, Popp, Bürkle: "Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span." dans: Mechanisms of ageing and development, Vol. 131, Issue 5, pp. 366-9, (2010) (PubMed).

Kondo, Obitsu, Ohta, Matsunami, Otsuka, Teshima: "Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition." dans: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13079-91, (2010) (PubMed).

Zaalishvili, Margiani, Kutalia, Suladze, Zaalishvili: "Automodification of PARP-1 mediates its tight binding to the nuclear matrix." dans: Biochemical and biophysical research communications, Vol. 393, Issue 1, pp. 123-5, (2010) (PubMed).

Drel, Xu, Zhang, Pavlov, Shevalye, Slusher, Obrosova: "Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy." dans: Endocrinology, Vol. 150, Issue 12, pp. 5273-83, (2009) (PubMed).

Adamczyk, Kaźmierczak: "Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway." dans: Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences, Vol. 47, Issue 3, pp. 247-51, (2009) (PubMed).

Détails sur PARP1

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Autre désignation: PARP1

Sujet: Catalyzes poly (ADP-ribose) protein modification, plays a role in DNA repair and genome stability [RGD].

Poids moléculaire: 112660

NCBI Accession: NP_037195

UniProt: P27008

Pathways: Apoptose, Caspase Cascade in Apoptosis, Réparation de l'ADN, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location