SEMA7A anticorps (N-Term)

N° du produit ABIN1881787

Détail du produit anti-SEMA7A anticorps

Antigène: SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))

Épitope: AA 178-202, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SEMA7A est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SEMA7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-202 amino acids from the N-terminal region of human SEMA7A.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SEMA7A (ABIN1881787)

Esnault, Torr, Bernau, Johansson, Kelly, Sandbo, Jarjour: "Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation." dans: PLoS ONE, Vol. 12, Issue 1, pp. e0170207, (2017) (PubMed).

Seltsam, Strigens, Levene, Yahalom, Moulds, Moulds, Hustinx, Weisbach, Figueroa, Bade-Doeding, DeLuca, Blasczyk: "The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens." dans: Transfusion, Vol. 47, Issue 1, pp. 133-46, (2007) (PubMed).

Yamada, Kubo, Takeshita, Harashima, Kawano, Mine, Sagawa, Sugamura, Itoh: "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 7, pp. 4094-100, (1999) (PubMed).

Angelisová, Drbal, Cerný, Hilgert, Horejsí: "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules." dans: Immunobiology, Vol. 200, Issue 2, pp. 234-45, (1999) (PubMed).

Lange, Liehr, Goen, Gebhart, Fleckenstein, Ensser: "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses." dans: Genomics, Vol. 51, Issue 3, pp. 340-50, (1998) (PubMed).

Détails sur SEMA7A

Antigène: SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))

Autre désignation: SEMA7A (SEMA7A Produits)

Synonymes: anticorps 2900057C09Rik, anticorps CDw108, anticorps H-Sema-L, anticorps M-Sema-L, anticorps Semal, anticorps CD108, anticorps H-SEMA-K1, anticorps JMH, anticorps SEMAK1, anticorps SEMAL, anticorps sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A, anticorps semaphorin 7A (John Milton Hagen blood group), anticorps Sema7a, anticorps SEMA7A

Sujet: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

Poids moléculaire: 74824

NCBI Accession: NP_001139501, NP_001139502, NP_003603

UniProt: O75326

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size