NPM1 anticorps

N° du produit ABIN1882271

Détail du produit anti-NPM1 anticorps

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NPM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: Purified His-tagged NPM1 protein was used to produced this monoclonal antibody.

Clone: 1042CT5-2-1

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-NPM1 (ABIN1882271)

Bolli, Galimberti, Martelli, Tabarrini, Roti, Mecucci, Martelli, Petrini, Falini: "Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia." dans: The lancet oncology, Vol. 7, Issue 4, pp. 350-2, (2006) (PubMed).

Swaminathan, Kishore, Febitha, Kundu: "Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription." dans: Molecular and cellular biology, Vol. 25, Issue 17, pp. 7534-45, (2005) (PubMed).

Tago, Chiocca, Sherr: "Sumoylation induced by the Arf tumor suppressor: a p53-independent function." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 21, pp. 7689-94, (2005) (PubMed).

Détails sur NPM1

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Autre désignation: NPM1 (NPM1 Produits)

Synonymes: anticorps B23, anticorps NPM, anticorps NO38, anticorps Npm, anticorps B23NP, anticorps npm4, anticorps npm, anticorps CG7917, anticorps CRP1, anticorps Crp1, anticorps Dmel\\CG7917, anticorps dNLP, anticorps dNLP-S, anticorps p22, anticorps npm1, anticorps sb:cb487, anticorps nucleophosmin 1, anticorps nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog, anticorps nucleophosmin 1b, anticorps Nucleophosmin, anticorps nucleophosmin, anticorps nucleophosmin (nucleolar phosphoprotein B23, numatrin), anticorps Nucleoplasmin, anticorps nucleophosmin 1a, anticorps NPM1, anticorps Npm1, anticorps npm1.L, anticorps npm1b, anticorps npm, anticorps Nlp, anticorps npm1a

Sujet: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.

Poids moléculaire: 32575

NCBI Accession: NP_001032827, NP_002511, NP_954654

UniProt: P06748

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly