SKA1 anticorps (C-Term)

N° du produit ABIN1886924

Détail du produit anti-SKA1 anticorps

Antigène: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKA1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide from near the carboxy terminus of human SKA1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur SKA1

Antigène: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Autre désignation: SKA1 (SKA1 Produits)

Synonymes: anticorps C18H18orf24, anticorps C18orf24, anticorps 2810433K01Rik, anticorps AV117428, anticorps RGD1310784, anticorps spindle and kinetochore associated complex subunit 1, anticorps SKA1, anticorps ska1, anticorps Ska1

Sujet: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes.Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs.A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset.Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure.Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.
Synonyms: Spindle and kinetochore associated complex subunit 1

UniProt: Q96BD8

Pathways: M Phase