STEAP1 anticorps (C-Term)

N° du produit ABIN1887239

Détail du produit anti-STEAP1 anticorps

Antigène: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STEAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): This STEAP1 antibody does not cross-react with other STEAP proteins.

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide from near the carboxy terminus of human STEAP1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur STEAP1

Antigène: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Autre désignation: STEAP1 (STEAP1 Produits)

Synonymes: anticorps PRSS24, anticorps STEAP, anticorps STEAP1, anticorps 2410007B19Rik, anticorps Prss24, anticorps Steap, anticorps STEAP family member 1, anticorps six transmembrane epithelial antigen of the prostate 1, anticorps STEAP1, anticorps Steap1

Sujet: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue.The normal function of STEAP is still uncertain, unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity.However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers.Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy.At least three isoforms of STEAP1 are known to exist.
Synonyms: Six transmembrane epithelial antigen of prostate 1, STEAP

Pathways: Transition Metal Ion Homeostasis